With the train an hour trip from Milan and 1,30 hour trip from the airport Malpensa, train stop Stresa.
From the station it is a 1km walk (10 minutes) through the historicl center of Stresa or passing by the lake front.
To view the route on Google maps click here
By car it takes 1 hour from Milan and 50 minutes from the airport Malpensa.
In both cases you take the highway A8/E62 direction Gravellona and take the exit Carpugnino, then follow Stresa.
To open the map on Google click here